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1.
Rev. bioét. derecho ; (50): 99-112, nov. 2020.
Artigo em Espanhol | IBECS | ID: ibc-191348

RESUMO

En el marco de una pandemia a escala mundial como la que representa el COVID-19 uno de los mayores dilemas bioéticos que se plantean es el de la gestión de determinados medios asistenciales escasos, tales como los respiradores (ventilación mecánica asistida), pues del acceso a los mismos dependen las posibilidades de supervivencia de numerosos pacientes en estado crítico. El presente trabajo trata de determinar los criterios para la gestión de dichos soportes vitales en un contexto de escasez extrema de los mismos para hacer frente a las necesidades de la totalidad de los pacientes que los requieren, analizando la literatura comparada sobre el particular, así como diferentes informes institucionales y de organismos en la esfera de la bioética


In the context of a worldwide pandemic such as COVID-19, one of the greatest bioethical dilemmas that arise is the management of certain scarce medical devices, such as ventilators (mechanical ventilation), since the survival of many critically ill patients depends on the access to these ventilators. The present paper tries to determine the criteria applicable for the management of these medical devices in a context of extreme scarcity to face the needs of all the patients who require them. To this end, the comparative literature on the subject as well as different institutional and academic reports in the field of bioethics are analysed


En el marc d'una pandèmia a escala mundial com la que representa la COVID-19 un dels majors dilemes bioètics que es plantegen és el de la gestió de determinats mitjans assistencials escassos, com ara els respiradors (ventilació mecànica assistida), ja que de l'accés als mateixos depenen les possibilitats de supervivència de nombrosos pacients en estat crític. El present treball pretén determinar els criteris per a la gestió d'aquests suports vitals en un context d'escassetat extrema dels mateixos per fer front a les necessitats de la totalitat dels pacients que els requereixen, analitzant la literatura comparada sobre el particular, així com diferents informes institucionals I d'organismes en l'esfera de la bioètica


Assuntos
Humanos , Sistemas de Manutenção da Vida/estatística & dados numéricos , Administração dos Cuidados ao Paciente , Infecções por Coronavirus/terapia , Pneumonia Viral/terapia , Pandemias , Triagem , Respiração Artificial , Ventiladores Mecânicos/provisão & distribuição , Unidades de Terapia Intensiva/provisão & distribuição
2.
Rev. esp. anestesiol. reanim ; 67(6): 301-315, jun.-jul. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-199522

RESUMO

OBJETIVO: Este estudio tuvo como objetivo identificar formas de mejorar el sistema de emergencia médica (SEM) en sus diferentes componentes, e inferir las causas de fallo de activación del equipo de emergencia médica (EEM). MÉTODOS: Se realizó un cuestionario sobre opiniones y actitudes hacia el SEM, dirigido a todos los profesionales del hospital, que tiene un SEM implementado con soporte vital básico (SVB) desde 1998. RESULTADOS: El 32% (n=585) de los profesionales del hospital respondió, de estos el 37,8% no eran médicos ni enfermeras. En promedio pasaron 6 años desde la certificación SVB, sin embargo, 102 profesionales (17,4%) no lo habían hecho. Un porcentaje relevante admitió no estar familiarizado con los diferentes componentes del SEM (criterios de activación 16,4%, número de teléfono 4,1%, contenido de los aparatos de reanimación 42,4% y monitor desfibrilador 47,4%), porcentajes disminuidos entre aquellos que habían tomado el curso SVB. La mayoría de los profesionales valoraran la EEM como muy importante, sin embargo 83 (23%) no pudieron confirmar que el informe y 17 (4,4%) que la asignación de tareas sucedió después y durante la activación, respectivamente. Al activar la EEM 52 (18,1%) admitieron temor a las críticas y 38 (13,3%) acordaron que necesitaban validación por parte de otro profesional, factores no influenciados por la finalización del curso SVB. Ciento veintisiete (45,7%) de los encuestados señalaron una carga de trabajo excesiva como barrera para reconocer a los pacientes enfermos. CONCLUSIÓN: A pesar de los esfuerzos educativos y de auditoría, el SEM no está completamente integrado en la cultura hospitalaria. La certificación SVB para todos los profesionales y las habilidades no técnicas de EEM identificadas son áreas de potencial mejoría del SEM. La falta de familiaridad con los criterios de activación, el miedo a las críticas y la carga de trabajo excesiva se identificaron como fallos en las causas de activación


OBJECTIVE: This study aimed to identify ways to improve the Medical Emergency System (MES) in its different components and infer Medical Emergency Team (MET) activation failure causes. METHODS: A questionnaire regarding opinions and attitudes towards the MES was conducted, targeting all professionals at the hospital, which has an implemented MES with Basic Life Support (BLS) since 1998. RESULTS: Thirty two percent (n=585) of hospital professionals answered, from these 37.8% were neither doctors nor nurses. In mean six years passed since the BLS certification, yet 102 professionals (17.4%) had not done it. A relevant percentage admitted to not being familiarized with the different components of the MES (activation criteria 16.4%, telephone number 4.1%, content of the resuscitation trolleys 42.4% and defibrillator-monitor 47.4%), percentages lessened among those had taken the BLS course. The majority highly valued MET, however 83 (23%) could not confirm that debriefingand 17 (4.4%) that allocation of tasks happened after and during activation, respectively. When activating MET 52 (18.1%) admitted fear of criticism and 38 (13.3%) agreed that they needed validation by another professional, factors not influenced by BLS course completion. Excessive workload as a barrier to recognize ill patients was pointed by 127 (45.7%) of the respondents. CONCLUSION: Despite educational and auditing efforts, the MES is not fully integrated into hospital culture. BLS certification for all professionals and non-technical skills of MET were identified has major areas for MES improvement. Unfamiliarity with activation criteria, fear of criticism and excessive workload were identified as failure of activation causes


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Melhoria de Qualidade/organização & administração , Serviço Hospitalar de Emergência/organização & administração , Tratamento de Emergência/métodos , Sistemas de Manutenção da Vida/estatística & dados numéricos , Equipe de Assistência ao Paciente/estatística & dados numéricos , Pesquisas sobre Atenção à Saúde/estatística & dados numéricos , Capacidade de Resposta ante Emergências/organização & administração
4.
J Palliat Care ; 34(4): 232-240, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30767641

RESUMO

AIM: Pancreas cancer continues to carry a poor prognosis. Hospitalized patients with advanced chronic pancreatic illnesses increasingly receive palliative care due to its perceived clinical benefits. Meanwhile, a growing proportion of elderly patients are reportedly receiving life-sustaining procedures. Temporal trends in the utilization of life-sustaining procedures and palliative care consultation among dying patients with advanced chronic pancreatic illnesses in US hospitals were examined. METHODS AND MATERIALS: A serial, cross-sectional analysis was carried out using the National Inpatient Sample Database. Decedents 18 years and older with a principal diagnosis of pancreas cancer or other advanced chronic pancreatic illnesses from 2005 through 2014. The compound annual growth rates (CAGRs) and Cochrane-Armitage correction of χ2 statistic were used. The receipt of life-sustaining systemic procedures, intra-abdominal local procedures and surgeries, and palliative care consultation were examined. Multilevel multivariate logistic regressions were performed to examine the association of various procedures with the utilization of palliative care consultation. RESULTS: Among 77 394 183 hospitalizations, 29 515 patients were examined. The CAGRs of systemic procedures, intra-abdominal procedures, surgeries, and palliative care were -4.19% (P = .008), 2.17%, -1.40%, and 14.03% (P < .001), respectively. The receipt of systemic procedures (odds ratio [OR] = 2.40, 95% confidence interval [CI], 2.08-2.74), local intra-abdominal procedures (OR = 1.46, 95% CI, 1.27-1.70), and surgeries (OR = 2.51, 95% CI, 2.07-3.05) was associated with palliative care consultation (Ps < .001). CONCLUSIONS: Among adults with pancreatic cancer or other advanced chronic pancreatic illnesses in the US hospitals from 2005 to 2014, the utilization of life-sustaining systemic procedures decreased while the prevalence of palliative care consultation increased.


Assuntos
Hospitais/estatística & dados numéricos , Sistemas de Manutenção da Vida/estatística & dados numéricos , Cuidados Paliativos/estatística & dados numéricos , Pancreatopatias/psicologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Doente Terminal/psicologia , Doente Terminal/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Previsões , Hospitais/tendências , Humanos , Masculino , Pessoa de Meia-Idade , Cuidados Paliativos/tendências , Estados Unidos , Adulto Jovem
5.
PLoS One ; 13(5): e0196778, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29746522

RESUMO

BACKGROUND: Extracorporeal life support (ECLS) provides emergency pulmonary and cardiac assistance for patients in respiratory or cardiac failure. Most studies evaluate the success of ECLS based on patients' survival rate. However, the trajectory of health status and quality of life (QOL) should also be important considerations. The study's aim was to explore changes in health status and QOL in adult patients weaned from ECLS who survived to hospital discharge over a one-year period. STUDY DESIGN: A prospective longitudinal study was conducted from April 2012 to September 2014. A convenience sample of patients who had undergone ECLS was followed for one-year after hospital discharge. Heath status was measured with a physical activity scale, the Centre for Epidemiologic Studies Depression scale, and a social support scale; we assessed quality of life with the physical and mental component summary scales of the Short-Form 36 Health Survey. Changes in depression, social support, physical activity and QOL were analysed with generalized estimating equations at 3-month intervals; participants' QOL at 12 months after discharge was compared with the general population. RESULTS: A total of 231 patients received ECLS during the study period. Sixty-five patients survived to hospital discharge (28% survival rate); 32 participants completed the study. Data showed scores for physical activity increased significantly over time (p < .001), while depression and social support significantly decreased (p < .05 and p < .001, respectively). Participants with veno-venous ECLS had higher scores for depression than participants with veno-arterial ECLS (p < .05). PCS scores significantly increased at 9, and 12 months after discharge (p < .05 and p < .001, respectively). There was no significant change in MCS scores. CONCLUSIONS: This was a preliminary study of patients with ECLS following hospital discharge over a one-year period. One year following hospital discharge survivors of ECLS continued to experience physical complications and some continued to have depressive symptoms; the level of social support was significantly lower after hospital discharge. Healthcare professionals should understand the trajectory of health status and QOL after discharge, which can help developing evidence-based interventions and improve QOL for survivors of ECLS.


Assuntos
Nível de Saúde , Sistemas de Manutenção da Vida/estatística & dados numéricos , Qualidade de Vida , Depressão/fisiopatologia , Feminino , Inquéritos Epidemiológicos/estatística & dados numéricos , Insuficiência Cardíaca/mortalidade , Insuficiência Cardíaca/fisiopatologia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Alta do Paciente/estatística & dados numéricos , Estudos Prospectivos , Taxa de Sobrevida , Sobreviventes/estatística & dados numéricos
6.
J Nepal Health Res Counc ; 15(2): 182-186, 2017 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-29016592

RESUMO

BACKGROUND: An effective ambulance is a vital requirement for providing an emergency medical service. Well-equipped ambulances with trained paramedics can save many lives during the golden hours of trauma care. The objective was to document the availability and utilization of basic life support equipment in the ambulances and to assess knowledge on first aid among the drivers. METHODS: Descriptive design was used. Total of 109 ambulances linked to B.P. Koirala Institute of Health Sciences were enrolled using purposive sampling method. Self- constructed observation checklist and semi structured interview schedule was used for data collection. RESULTS: More than half of the respondents had less than five years of experience and were not trained in first aid. About two-third of the respondents had adequate knowledge on first aid. About 90% of the ambulance had oxygen cylinder and adult oxygen mask which was 'usually' used equipment. More than half of ambulance had equipment less than 23% as compared to that of national guidelines. There was significant association of knowledge with the experience (p = 0.004) and training (p = 0.001). Availability of equipment was associated with training received (p = 0.007),organization (p= 0.032)and district (p = 0.023) in which the ambulance is registered. CONCLUSIONS: The study concludes that maximum ambulance linked to BPKIHS, Nepal did not have even one fourth of the equipment for basic life support. Equipment usually used was oxygen cylinder and oxygen mask. Majority of driver had adequate knowledge on first aid and it was associated with training and experience.


Assuntos
Ambulâncias/estatística & dados numéricos , Serviços Médicos de Emergência/estatística & dados numéricos , Auxiliares de Emergência/estatística & dados numéricos , Conhecimentos, Atitudes e Prática em Saúde , Sistemas de Manutenção da Vida/estatística & dados numéricos , Adulto , Ambulâncias/normas , Serviços Médicos de Emergência/normas , Auxiliares de Emergência/educação , Auxiliares de Emergência/normas , Feminino , Primeiros Socorros/métodos , Humanos , Sistemas de Manutenção da Vida/normas , Masculino , Pessoa de Meia-Idade , Nepal
7.
Prehosp Emerg Care ; 21(5): 563-566, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28414559

RESUMO

BACKGROUND: The Michigan Legislature mandated that all public schools stock epinephrine auto-injectors (EAIs). A minimal amount is known regarding the incremental value of EAIs in schools. Our primary objective was to describe the frequency of administration of epinephrine for EMS patients with acute allergic reactions in public schools. Our secondary objective was to estimate the cost of mandating public schools to stock EAIs. METHODS: We performed a retrospective cohort study of EMS cases with an impression of allergic reaction and who received epinephrine recorded in the 2014 Michigan EMS Information System (MI-EMSIS). We abstracted patient demographics, incident location by address to identify public schools, source of epinephrine given, and suspected allergen if known. We calculated advanced life support (ALS) response times to assess temporal impact of school EAIs in communities with ALS systems. We estimated the unsubsidized annual procurement cost of this mandate for Michigan public schools (N = 4,039), using range of costs for the required 2 EAIs (adult and pediatric) as estimated by the legislature ($140/each) and recently reported costs for commercial sources ($1,200). Training costs were not included. Descriptive statistics are reported. RESULTS: During this period, there were 1,550,009 EMS cases in the state with 631 receiving non-cardiac arrest epinephrine for presumed anaphylaxis, of which 23 cases were in public schools. Reported allergens were most often food 12 (51.2%), insect stings 4(22.2%) or unknown 7(30.4%). Among these patients, the source for epinephrine used was from the student, 7 (30.4%), EMS 7 (30.4%), school 7(30.4%), and unknown 2(8.7%). A majority (21, 91.3%) of the public school cases occurred in communities with ALS systems and ALS response was relatively rapid (median response 6 minutes, 90 percentile, 13 minutes). The unsubsidized annual cost of Michigan public schools to stock EAIs ranges from $565,460 to $4,846,800. CONCLUSION: In this study, few public school patients received epinephrine for anaphylaxis and the vast majority occurred in communities with rapid ALS response. The direct annual supply cost of the school EAI mandate is substantial.


Assuntos
Anafilaxia/tratamento farmacológico , Serviços Médicos de Emergência/estatística & dados numéricos , Epinefrina/administração & dosagem , Sistemas de Manutenção da Vida/estatística & dados numéricos , Serviços de Saúde Escolar/economia , Adolescente , Adulto , Alérgenos , Anafilaxia/economia , Criança , Estudos de Coortes , Efeitos Psicossociais da Doença , Serviços Médicos de Emergência/economia , Epinefrina/economia , Feminino , Humanos , Sistemas de Manutenção da Vida/economia , Masculino , Michigan , Estudos Retrospectivos , Serviços de Saúde Escolar/estatística & dados numéricos , Instituições Acadêmicas , Adulto Jovem
8.
Prehosp Emerg Care ; 20(5): 623-9, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27074549

RESUMO

AIM: Futile resuscitation can lead to unnecessary transports for out-of-hospital cardiac arrest (OHCA). The Basic Life Support (BLS) and Advanced Life Support (ALS) termination of resuscitation (TOR) guidelines have been validated with good results in North America. This study aims to evaluate the performance of these two rules in predicting neurological outcomes of OHCA patients in Singapore, which has an intermediate life support Emergency Medical Services (EMS) system. METHODS: A retrospective cohort study was carried out on Singapore OHCA data collected from April 2010 to May 2012 for the Pan-Asian Resuscitation Outcomes Study (PAROS). The outcomes of each rule were compared to the actual neurological outcomes of the patients. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and predicted transport rates of each test were evaluated. RESULTS: A total of 2,193 patients had cardiac arrest of presumed cardiac etiology. TOR was recommended for 1,411 patients with the BLS-TOR rule, with a specificity of 100% (91.9, 100.0) for predicting poor neurological outcomes, PPV 100% (99.7, 100.0), sensitivity 65.7% (63.6, 67.7), NPV 5.6% (4.1, 7.5), and transportation rate 35.6%. Using the ALS-TOR rule, TOR was recommended for 587 patients, specificity 100% (91.9, 100.0) for predicting poor neurological outcomes, PPV 100% (99.4, 100.0), sensitivity 27.3% (25.4, 29.3), NPV 2.7% (2.0, 3.7), and transportation rate 73.2%. BLS-TOR predicted survival (any neurological outcome) with specificity 93.4% (95% CI 85.3, 97.8) versus ALS-TOR 98.7% (95% CI 92.9, 99.8). CONCLUSION: Both the BLS and ALS-TOR rules had high specificities and PPV values in predicting neurological outcomes, the BLS-TOR rule had a lower predicted transport rate while the ALS-TOR rule was more accurate in predicting futility of resuscitation. Further research into unique local cultural issues would be useful to evaluate the feasibility of any system-wide implementation of TOR.


Assuntos
Reanimação Cardiopulmonar/estatística & dados numéricos , Técnicas de Apoio para a Decisão , Sistemas de Manutenção da Vida/estatística & dados numéricos , Parada Cardíaca Extra-Hospitalar/terapia , Ordens quanto à Conduta (Ética Médica) , Idoso , Estudos de Coortes , Serviços Médicos de Emergência/normas , Feminino , Humanos , Masculino , Parada Cardíaca Extra-Hospitalar/mortalidade , Avaliação de Resultados em Cuidados de Saúde , Valor Preditivo dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade , Singapura , Taxa de Sobrevida
9.
Int J Cardiol ; 204: 70-6, 2016 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-26655543

RESUMO

BACKGROUND: Cardiopulmonary resuscitation displays low survival rate after out-of-hospital cardiac arrest (OHCA). Extracorporeal life support (ECLS) could be suggested as a rescue therapeutic option in refractory OHCA. The aim of this report is to analyze our experience of ECLS implantation for refractory OHCA. METHODS: We performed a retrospective observational analysis of our prospectively collected database. Patients were divided into a shockable rhythm (SH-R) and a non-shockable rhythm (NSH-R) group according to cardiac rhythm at ECLS implantation. The primary endpoint was survival to hospital discharge with good neurological recovery. RESULTS: From January 2010 to December 2014 we used ECLS in 68 patients (SH-R, n=19, 27.9% vs. NSH-R, n=49, 72.1%) for refractory OHCA. The clinical profile before ECLS implantation was comparable between the groups. Eight (11.7%) patients were successfully weaned from ECLS (SH-R=31.5% vs. NSH-R=4.0%, p=0.01) after a mean period of support of 2.1 days (SH-R=4.1 days vs. NSH-R=1.4 days, p=0.01). Six (8.8%) patients survived to discharge (SH-R=31.5% vs. NSH-R=0%, p=0.00). In the SH-R group 50% of the survivors were discharged without neurological complications. CONCLUSIONS: ECLS for refractory OHCA should be limited in consideration of its poor, especially neurological, outcome. Non-shockable rhythms could be considered as a formal contraindication allowing a concentration of our efforts on the shockable rhythms, where the chances of success are substantial.


Assuntos
Oxigenação por Membrana Extracorpórea/mortalidade , Oxigenação por Membrana Extracorpórea/tendências , Sistemas de Manutenção da Vida , Parada Cardíaca Extra-Hospitalar/mortalidade , Parada Cardíaca Extra-Hospitalar/terapia , Adulto , Idoso , Oxigenação por Membrana Extracorpórea/estatística & dados numéricos , Feminino , Seguimentos , Humanos , Sistemas de Manutenção da Vida/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Parada Cardíaca Extra-Hospitalar/diagnóstico , Estudos Prospectivos , Estudos Retrospectivos , Taxa de Sobrevida/tendências , Resultado do Tratamento , Adulto Jovem
11.
Pediatr Crit Care Med ; 16(4): 366-74, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25599148

RESUMO

OBJECTIVE: To determine the effect of therapeutic plasma exchange on hemodynamics, organ failure, and survival in children with multiple organ dysfunction syndrome due to sepsis requiring extracorporeal life support. DESIGN: A retrospective analysis. SETTING: A PICU in an academic children's hospital. PATIENTS: Fourteen consecutive children with sepsis and multiple organ dysfunction syndrome who received therapeutic plasma exchange while on extracorporeal life support from 2005 to 2013. INTERVENTIONS: Median of three cycles of therapeutic plasma exchange with median of 1.0 times the estimated plasma volume per exchange. MEASUREMENTS AND MAIN RESULTS: Organ Failure Index and Vasoactive-Inotropic Score were measured before and after therapeutic plasma exchange use. PICU survival in our cohort was 71.4%. Organ Failure Index decreased in patients following therapeutic plasma exchange (mean ± SD: pre, 4.1 ± 0.7 vs post, 2.9 ± 0.9; p = 0.0004). Patients showed improved Vasoactive-Inotropic Score following therapeutic plasma exchange (median [25th-75th]: pre, 24.5 [13.0-69.8] vs post, 5.0 [1.5-7.0]; p = 0.0002). Among all patients, the change in Organ Failure Index was greater for early therapeutic plasma exchange use than late use (early, -1.7 ± 1.2 vs late, -0.9 ± 0.6; p = 0.14), similar to the change in Vasoactive-Inotropic Score (early, -67.5 [28.0-171.2] vs late, -12.0 [7.2-18.5]; p = 0.02). Among survivors, the change in Organ Failure Index was greater among early therapeutic plasma exchange use than late use (early, -2.3 ± 1.0 vs late, -0.8 ± 0.8; p = 0.03), as was the change in Vasoactive-Inotropic Score (early, -42.0 [16.0-76.3] vs late, -12.0 [5.3-29.0]; p = 0.17). The mean duration of extracorporeal life support after therapeutic plasma exchange according to timing of therapeutic plasma exchange was not statistically different among all patients or among survivors. CONCLUSIONS: The use of therapeutic plasma exchange in children on extracorporeal life support with sepsis-induced multiple organ dysfunction syndrome is associated with organ failure recovery and improved hemodynamic status. Initiating therapeutic plasma exchange early in the hospital course was associated with greater improvement in organ dysfunction and decreased requirement for vasoactive and/or inotropic agents.


Assuntos
Hemodinâmica , Sistemas de Manutenção da Vida/estatística & dados numéricos , Insuficiência de Múltiplos Órgãos/terapia , Troca Plasmática/estatística & dados numéricos , Sepse/complicações , Adolescente , Criança , Pré-Escolar , Terapia Combinada/métodos , Feminino , Humanos , Lactente , Tempo de Internação/estatística & dados numéricos , Masculino , Insuficiência de Múltiplos Órgãos/etiologia , Insuficiência de Múltiplos Órgãos/fisiopatologia , Estudos Retrospectivos , Índice de Gravidade de Doença , Taxa de Sobrevida , Resultado do Tratamento
12.
Support Care Cancer ; 23(6): 1779-85, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25471179

RESUMO

PURPOSE: The purposes of this study were to evaluate, in colorectal cancer patients, the cause of ICU admission and to find predictors of death during and after hospitalization. METHODS: This is a retrospective study including all patients with colorectal cancer admitted in the ICU of a cancer hospital from January 1st 2003 to December 31 2012. RESULTS: Among 3721 ICU admissions occurring during the study period, 119 (3.2 %) admissions dealt with colorectal cancer, of whom 89 were eligible and assessable. The main reasons for admission were of metabolic (24 %), hemodynamic (19 %), cardiovascular (18 %), gastrointestinal (16 %), respiratory (13 %), or neurologic (6 %) origin. These complications were due to cancer in 43 %, to the antineoplastic treatment in 25 %, or were unrelated to the cancer or its treatment in 33 %. A quarter of the patients died during hospitalization. Independent predictors of death were the Sequential Organ Failure Assessment (SOFA) score (with risk of dying increasing by 42 % per unit of SOFA score), fever (with risk of dying multiplied by three per °C), and high values of GOT (with risk of dying multiplied by 1 % per unit increase), while cancer control (i.e., stage progression or not), compliance to the initial cancer treatment plan, and LDH ≤ median levels had prognostic significance for further longer survival after hospital discharge. CONCLUSION: This is the first study looking at specific causes for unplanned ICU admission of patients with colorectal cancer. Hospital mortality was influenced by the characteristics of the complication that entailed the ICU admission while cancer characteristics retained their prognostic influence on survival after hospital discharge.


Assuntos
Neoplasias Colorretais/terapia , Mortalidade Hospitalar , Unidades de Terapia Intensiva/estatística & dados numéricos , Admissão do Paciente/estatística & dados numéricos , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Colorretais/mortalidade , Feminino , Humanos , Tempo de Internação/estatística & dados numéricos , Sistemas de Manutenção da Vida/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Alta do Paciente , Prognóstico , Estudos Retrospectivos , Adulto Jovem
13.
Crit Care ; 18(5): 548, 2014 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-25341381

RESUMO

INTRODUCTION: Extracorporeal life support (ECLS) can temporarily support cardiopulmonary function, and is occasionally used in resuscitation. Multi-scale entropy (MSE) derived from heart rate variability (HRV) is a powerful tool in outcome prediction of patients with cardiovascular diseases. Multi-scale symbolic entropy analysis (MSsE), a new method derived from MSE, mitigates the effect of arrhythmia on analysis. The objective is to evaluate the prognostic value of MSsE in patients receiving ECLS. The primary outcome is death or urgent transplantation during the index admission. METHODS: Fifty-seven patients receiving ECLS less than 24 hours and 23 control subjects were enrolled. Digital 24-hour Holter electrocardiograms were recorded and three MSsE parameters (slope 5, Area 6-20, Area 6-40) associated with the multiscale correlation and complexity of heart beat fluctuation were calculated. RESULTS: Patients receiving ECLS had significantly lower value of slope 5, area 6 to 20, and area 6 to 40 than control subjects. During the follow-up period, 29 patients met primary outcome. Age, slope 5, Area 6 to 20, Area 6 to 40, acute physiology and chronic health evaluation II score, multiple organ dysfunction score (MODS), logistic organ dysfunction score (LODS), and myocardial infarction history were significantly associated with primary outcome. Slope 5 showed the greatest discriminatory power. In a net reclassification improvement model, slope 5 significantly improved the predictive power of LODS; Area 6 to 20 and Area 6 to 40 significantly improved the predictive power in MODS. In an integrated discrimination improvement model, slope 5 added significantly to the prediction power of each clinical parameter. Area 6 to 20 and Area 6 to 40 significantly improved the predictive power in sequential organ failure assessment. CONCLUSIONS: MSsE provides additional prognostic information in patients receiving ECLS.


Assuntos
Entropia , Circulação Extracorpórea/métodos , Frequência Cardíaca/fisiologia , Sistemas de Manutenção da Vida , Adulto , Idoso , Circulação Extracorpórea/estatística & dados numéricos , Feminino , Humanos , Sistemas de Manutenção da Vida/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Estudos Prospectivos
16.
Chest ; 146(3): 573-582, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24522751

RESUMO

BACKGROUND: The magnitude and implication of variation in end-of-life decision-making among ICUs in the United States is unknown. METHODS: We reviewed data on decisions to forgo life-sustaining therapy (DFLSTs) in 269,002 patients admitted to 153 ICUs in the United States between 2001 and 2009. We used fixed-effects logistic regression to create a multivariable model for DFLST and then calculated adjusted rates of DFLST for each ICU. RESULTS: Patient factors associated with increased odds of DFLST included advanced age, female sex, white race, and poor baseline functional status (all P < .001). However, associations with several of these factors varied among ICUs (eg, black race had an OR for DFLST from 0.18 to 2.55 across ICUs). The ICU staffing model was also found to be associated with DFLST, with an open ICU staffing model associated with an increased odds of a DFLST (OR = 1.19). The predicted probability of DFLST varied approximately sixfold among ICUs after adjustment for the fixed patient and ICU effects and was directly correlated with the standardized mortality ratios of ICUs (r = 0.53, 0.41-0.68). CONCLUSION: Although patient factors explain much of the variability in DFLST practices, significant effects of ICU culture and practice influence end-of-life decision-making. The observation that an ICU's risk-adjusted propensity to withdraw life support is directly associated with its standardized mortality ratio suggests problems with using the latter as a quality measure.


Assuntos
Adesão a Diretivas Antecipadas/tendências , Cuidados Críticos/métodos , Estado Terminal/terapia , Tomada de Decisões , Unidades de Terapia Intensiva/tendências , Sistemas de Manutenção da Vida/estatística & dados numéricos , Ordens quanto à Conduta (Ética Médica) , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Estado Terminal/epidemiologia , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Prognóstico , Grupos Raciais , Estudos Retrospectivos , Fatores Sexuais , Estados Unidos/epidemiologia
17.
Curr Aging Sci ; 2(3): 240-8, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20021418

RESUMO

OBJECTIVE: To identify variables associated with mortality in the ICU and 1 year following discharge. DESIGN: Prospective observational cohort study. SETTING: ICU of a tertiary care center and university hospital. PATIENTS: A total of 3,119 medical and neurological intensive care patients. MEASUREMENTS AND MAIN RESULTS: Pre-admission health status was quantified by the sum of risk factors and chronic diseases. Severity of the acute disease was estimated by counting the number of organ dysfunctions and the Acute Physiology Score. Concerning the primarily affected organ system, ICU mortality was highest in hematological diseases (63%) and 1-year mortality was 82%. Lowest death rates were observed with metabolic (ICU 4%, 1-yr 18%) and psychiatric diagnoses (ICU 5%, 1-yr 13%). Greater severity of illness with the need for mechanical life support was associated with decreased 1-year survival. In the respiratory and in renal diseases, the artificial support of the primarily affected organ system incurred an ICU mortality equaling the average (23%) or below (14%) that of the whole ICU population. Pre-admission health status increased the probability of developing multiple organ failure and worsened outcome 1 year after discharge in non-cardiovascular patients. Age showed a weak correlation with chronic diseases and severity of the acute illness and was related to long-term, but not short-term survival. CONCLUSIONS: The most important risk factors associated with short- and long-term mortality in non-surgical intensive care patients are disease severity and the primarily affected organ system that necessitates admission. The artificial support of this organ system can improve only short-term outcome.


Assuntos
Cuidados Críticos/estatística & dados numéricos , Estado Terminal/terapia , Unidades de Terapia Intensiva/estatística & dados numéricos , Sobreviventes/estatística & dados numéricos , APACHE , Fatores Etários , Idoso , Distribuição de Qui-Quadrado , Comorbidade , Estado Terminal/mortalidade , Feminino , Mortalidade Hospitalar , Humanos , Sistemas de Manutenção da Vida/estatística & dados numéricos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Alta do Paciente/estatística & dados numéricos , Estudos Prospectivos , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Análise de Sobrevida , Fatores de Tempo
20.
J Pain ; 9(4): 320-9, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18201933

RESUMO

UNLABELLED: Pain management is often described as a component of child life specialists' work. No research has described the specific pain management strategies used by child life specialists. The objectives of this study were to determine child life specialists' use of nonpharmacological strategies, to describe the perceived efficacy of these strategies, to determine how much training child life specialists had in these various strategies, and to determine what demographic characteristics predict the use of evidence-based techniques. Six hundred seven child life specialists from hospitals and health centers across North America responded to an online survey (response rate: 85.4%). Results indicate that child life specialists use a variety of techniques with varying degrees of perceived efficacy. The most commonly endorsed techniques were providing information/preparation, comforting/reassurance, and positive reinforcement. Respondents reported receiving substantial training in some techniques (eg, providing information/preparation, medical play) and high interest in receiving additional training in all techniques. Certification status, the proportion of patients for whom participants reported providing pain management services, and participants' perceived levels of knowledge and skill emerged as significant predictors of the use of evidence-based strategies. The results of this survey suggest that child life specialists are actively involved in pediatric pain management. PERSPECTIVE: American and Canadian child life specialists were surveyed to assess their involvement in managing the pain of pediatric patients. Findings of the survey indicate that child life specialists are involved in the management of pediatric pain and are receptive to additional training in evidence-based techniques.


Assuntos
Aconselhamento/estatística & dados numéricos , Dor Intratável/psicologia , Dor Intratável/terapia , Enfermagem Pediátrica/estatística & dados numéricos , Pediatria/estatística & dados numéricos , Especialização/estatística & dados numéricos , Adulto , Atitude do Pessoal de Saúde , Criança , Serviços de Saúde da Criança/estatística & dados numéricos , Serviços de Saúde da Criança/tendências , Proteção da Criança , Aconselhamento/métodos , Aconselhamento/tendências , Feminino , Pesquisas sobre Atenção à Saúde , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Serviços de Informação , Sistemas de Manutenção da Vida/estatística & dados numéricos , Masculino , América do Norte , Clínicas de Dor/estatística & dados numéricos , Clínicas de Dor/tendências , Medição da Dor/métodos , Medição da Dor/estatística & dados numéricos , Defesa do Paciente , Educação de Pacientes como Assunto/métodos , Educação de Pacientes como Assunto/normas , Educação de Pacientes como Assunto/tendências , Enfermagem Pediátrica/métodos , Enfermagem Pediátrica/tendências , Pediatria/métodos , Pediatria/tendências , Psicologia da Criança/métodos , Psicologia da Criança/estatística & dados numéricos , Psicologia da Criança/tendências , Especialização/tendências
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